Anti-inflammatory effect of licorice (Licorice common) root extract on acute carrageenan-induced inflammation in rat

Authors

  • Mohammad Khaksarie Hadad
  • Parvin Zareian
  • Reza Esmi Jahromie
  • Sohrab Esmailie Mahanie
Abstract:

There are some evidences regarding anti-allergic and anti-inflammatory effects of Licorice common in traditional medicine and its usefulness in Diabetes mellitus and Diabetes insipidus and its stimulatory effect on admeocortical gland. This medicinal plant contains glycyrrhizin, sterogenic substances, cumarins, flavonoids, sterols, choline, asparagine and glaberin. Glycyrrhizin and glaberin have analgesic and anti- inflammatory effects. In this study, we evaluated the effect of licorice root extract on acute carrageenan-induced inflammation in the rat's hind paw as compared to anti- inflammatory effect of ibuprofen. For this purpose, adult male rats were divided into eight groups. Paw edema was induced by intraplantar injection of 0.1 ml of 0.5% carrageenan solution. Different doses of licorice root extract (50, l00, 200, 300 mg/kg, i.p.) and ibuprofen (12 mg/kg, i.p.) were given ten minutes before injection of carrageenan. Assessment of edema was performed by evaluation of volume change as determined by plethysmometry and extravasations of Evans blue dye as measured by spectrophotometry and changes in paw weight in test groups as compared to the control group. The results showed that the extract exerts a significant inhibitory effect on hind paw edema (volume) in a dose-dependent manner. In this respect, the maximum inhibition (54%) was achieved at a dose of 300 mg/kg of the extract and this dose was comparable to ibuprofen at a dose of 12 mg/kg. Meanwhile, the extract administration significantly reduced Evans blue content (100, 200 and 300 mg/kg) as compared to the control group. It could be concluded that licorice root extract is able to inhibit acute inflammatory response in the rat hind paw, and these effects are comparable to ibuprofen.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Anti-Inflammatory Effects of Licorice and Roasted Licorice Extracts on TPA-Induced Acute Inflammation and Collagen-Induced Arthritis in Mice

The anti-inflammatory activity of licorice (LE) and roasted licorice (rLE) extracts determined in the murine phorbol ester-induced acute inflammation model and collagen-induced arthritis (CIA) model of human rheumatoid arthritis. rLE possessed greater activity than LE in inhibiting phorbol ester-induced ear edema. Oral administration of LE or rLE reduced clinical arthritis score, paw swelling, ...

full text

Anti-inflammatory effect of Allium akaka extract on the inflammation induced by carrageenan in rats

Background and objectives: Allium akaka, locally known “Valak” a member of the Amaryllidaceae family, is widely used in Iranian folk medicine for its wound healing, antibacterial, anthelmintic, and diuretic properties. The aim of the present work was to evaluate the anti-inflammatory effect of Allium akaka hydro-alcoholic extract on carrageenan-induce...

full text

The study of analgesic effect of licorice root extract in rat

Although non-steroidal anti-inflammatory drugs (NSAIDs) and opioid compounds are widely used in the releif of pain, they are not always useful due to their side effects. It seems necessary to search for newer analgesic compounds. Therefore, we decided to study the analgesic effects of this plant. For extraction, percolation method was used and different weights of dried extract were dissolved i...

full text

The study of analgesic effect of licorice root extract in rat

Although non-steroidal anti-inflammatory drugs (NSAIDs) and opioid compounds are widely used in the releif of pain, they are not always useful due to their side effects. It seems necessary to search for newer analgesic compounds. Therefore, we decided to study the analgesic effects of this plant. For extraction, percolation method was used and different weights of dried extract were dissolved i...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Effects of Space Flight on the Chemical Constituents and Anti-Inflammatory Activity of Licorice (Glycyrrhiza uralensis Fisch)

   Licorice, the oldest Chinese traditional medicine, is widely used in the treatment of human diseases. Due to the deficiency of wild resource, selecting and breeding becomes a key issue to expanding the supply of licorice. Spaceflight technology will become a new method for medicinal plants. The aim of this study was to investigate the effect of spaceflight on the components and anti-inflamma...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 7  issue None

pages  41- 46

publication date 2003-04

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023